Amitriptyline
| Evidence Level: N/A | Predicted Indications: 0 |
Table of Contents
- Amitriptyline
Amitriptyline: Known uses and market status in Australia
Summary
The TxGNN model has no candidate with a score of 0.99 or higher for Amitriptyline, so there is currently no new predicted indication. The drug’s recorded uses are listed below.
Quick overview
| Item | Content |
|---|---|
| New predicted indications | None (no model candidate scored 0.99 or higher) |
| Known uses recorded for this drug | 6 |
| Evidence level | Not applicable |
| Australia Market Status | Listed on the PBS Schedule (1 of 1 items) – TGA (ARTG) registration status is not included in this data |
| Number of PBS Items | 1 (valid: 1) |
Known uses recorded for this drug
Approved (supported by a licence or label)
| Indication | Source |
|---|---|
| depression | licence in another country |
| neuralgia | licence in another country |
Related to an approved indication (same disease category)
| Indication | Approved category |
|---|---|
| none | none |
Relations recorded in the knowledge graph (no approval found)
| Indication |
|---|
| anxiety disorder |
| dysthymic disorder |
| mixed anxiety and depressive disorder |
| neurotic disorder |
Australia Market Information
| Licence | Product | Dosage form | Status |
|---|---|---|---|
| 2417F | ENTRIP | Tablet containing amitriptyline hydrochl | Valid |
Safety Considerations
Contraindications recorded in the knowledge graph (these come from drug-disease contraindication edges, not from label text):
- Cardiac and conduction: long QT syndrome (including familial), torsades de pointes
- Blood pressure: orthostatic hypotension, postural orthostatic tachycardia syndrome, multiple system atrophy
- Neurological: epilepsy, basal ganglia disease, focal hand dystonia, blepharospasm
- Psychiatric: manic bipolar affective disorder, psychotic disorders, schizophreniform and schizoaffective disorders, substance abuse/dependence
- Metabolic and organ: porphyria (inherited), kidney disease, liver disease, gallbladder disease, hyperglycaemia, pyoureter
- Haematological: thrombocytopenia, neutropenia, agranulocytosis
- Other: open-angle glaucoma, benign prostatic hyperplasia, female breast carcinoma
Drug Interactions: 100 interactions were recorded in total. Examples classed as Major include epinephrine, bupropion, cisapride, dexfenfluramine, dolasetron and ephedrine. Examples classed as Moderate include famotidine, cimetidine, clarithromycin, atropine, dicyclomine, activated charcoal and the sulfonylureas acetohexamide and chlorpropamide.
Other points from the literature: cardiotoxicity, anticholinergic effects, poorer tolerability than many alternatives, overdose toxicity, and a case report of recreational abuse.
Please refer to the TGA-approved Product Information (PI) for label warnings and contraindications.
Disclaimer
This content is for research purposes only and does not constitute medical advice. Clinical validation is required before any clinical application.