Dicloxacillin
| Evidence Level: N/A | Predicted Indications: 0 |
Table of Contents
- Dicloxacillin
Dicloxacillin: Known uses and market status in Australia
Summary
The TxGNN deep-learning model has no candidate indication with a score of 0.99 or higher for Dicloxacillin, so there is currently no new predicted indication. The drug’s own recorded uses are listed below. They are existing records, not model candidates.
Quick overview
| Item | Content |
|---|---|
| New predicted indications | None (no model candidate scored 0.99 or higher) |
| Known uses recorded for this drug | 3 |
| Evidence level | Not applicable |
| Australia Market Status | Listed on the PBS Schedule (1 of 1 items) – TGA (ARTG) registration status is not included in this data |
| Number of PBS Items | 1 (valid: 1) |
Known uses recorded for this drug
Approved (supported by a licence or label)
| Indication | Source |
|---|---|
| none | none |
Related to an approved indication (same disease category)
| Indication | Approved category |
|---|---|
| none | none |
Relations recorded in the knowledge graph (no approval found)
| Indication |
|---|
| staphylococcal infection |
| staphylococcal pneumonia |
| staphylococcus aureus infection |
Australia Market Information
| Licence | Product | Dosage form | Status |
|---|---|---|---|
| 10790X | Distaph 500 | Capsule 500 mg (as sodium) | Valid |
Safety Considerations
No label-based warnings or contraindications are available in the data compiled for this report. Please refer to the TGA-approved Product Information (PI) for these.
- Knowledge-graph contraindication associations (these are not label text): kidney disease, pyoureter, Clostridium difficile colitis, perinatal necrotising enterocolitis, infectious mononucleosis, and chronic Epstein-Barr virus infection syndrome.
- Drug interactions: 41 interactions were identified in total. The most notable are rated Moderate:
- Tetracyclines: doxycycline, tetracycline, minocycline
- Balsalazide
- Picosulfuric acid
- Iodide I-131
- Minor: clarithromycin.
- Unknown severity: several others, including proton pump inhibitors (omeprazole, pantoprazole, lansoprazole), ranitidine, corticosteroids (prednisone, dexamethasone, triamcinolone), morphine, loperamide, ondansetron, metronidazole, misoprostol and rosuvastatin.
- Pharmacokinetic note: dicloxacillin is highly albumin-bound, so conditions affecting albumin may alter free-drug levels. A published case also describes subtherapeutic levels in a neonate.
Disclaimer
This content is for research purposes only and does not constitute medical advice. Clinical validation is required before any clinical application.