Escitalopram
| Evidence Level: N/A | Predicted Indications: 0 |
Table of Contents
- Escitalopram
Escitalopram: Known uses and market status in Australia
Summary
The TxGNN deep-learning model (score ≥ 0.99) produced candidates for Escitalopram. Every candidate that can be traced to a source is already a known use, so there is currently no new predicted indication. The two known uses are recorded as relations in the knowledge graph. No approval was found for either one.
Quick overview
| Item | Content |
|---|---|
| New predicted indications | None (all traceable model candidates are known uses) |
| Known uses among model candidates | 2 |
| Evidence level | Not applicable |
| Australia Market Status | Listed on the PBS Schedule (1 of 1 items) – TGA (ARTG) registration status is not included in this data |
| Number of PBS Items | 1 (valid: 1) |
Known uses among the model’s candidates
Approved (supported by a licence or label)
| Indication | Source |
|---|---|
| none | none |
Related to an approved indication (same disease category)
| Indication | Approved category |
|---|---|
| none | none |
Relations recorded in the knowledge graph (no approval found)
| Indication |
|---|
| endogenous depression |
| major depressive disorder |
Australia Market Information
| Licence | Product | Dosage form | Status |
|---|---|---|---|
| 10181W | Lexapro | Oral solution 20 mg (as oxalate) per mL, | Valid |
Safety Considerations
- Contraindication-related conditions (knowledge graph, not label text): epilepsy, bipolar disorder, major affective disorder, liver disease, gallbladder disease, blood coagulation disease, heart disease, cardiovascular disease, neuroleptic malignant syndrome, inappropriate ADH syndrome, nephrogenic syndrome of inappropriate antidiuresis, and serotonin syndrome.
- Drug interactions: 100 interactions were identified; 20 were reviewed. Major-level interactions include bupropion, lorcaserin, clarithromycin, diethylpropion, dolasetron, palonosetron and phentermine. Moderate interactions include acetylsalicylic acid (bleeding risk), morphine, omeprazole, cimetidine, famotidine, loperamide and glimepiride, among others. The remaining interactions were not reviewed.
- Other considerations: One literature source notes that SSRIs, including escitalopram, may cause galactorrhoea. Doses above labelled limits (relevant to OCD, not dysthymia) raise QT-prolongation concerns.
Warnings and contraindications from the TGA-approved Product Information (PI) were not available. Please refer to the PI for full safety information.
Disclaimer
This content is for research purposes only and does not constitute medical advice. Clinical validation is required before any clinical application.