Risedronic Acid: Known uses and market status in Australia
Summary
The TxGNN deep-learning model (score ≥ 0.99) produced candidates for Risedronic Acid. Every candidate that can be traced to a source is already a known use, so there is currently no new predicted indication. The one known use is recorded as a relation in the knowledge graph, and no approval was found for it.
Quick overview
Item
Content
New predicted indications
None (all traceable model candidates are known uses)
Known uses among model candidates
1
Evidence level
Not applicable
Australia Market Status
Listed on the PBS Schedule (1 of 1 items) – TGA (ARTG) registration status is not included in this data
Number of PBS Items
1 (valid: 1)
Known uses among the model’s candidates
Approved (supported by a licence or label)
Indication
Source
none
none
Related to an approved indication (same disease category)
Indication
Approved category
none
none
Relations recorded in the knowledge graph (no approval found)
Indication
bone Paget disease
Australia Market Information
Licence
Product
Dosage form
Status
13360E
Actonel
Tablet containing risedronate sodium 5 m
Valid
Safety Considerations
Contraindications flagged by the knowledge graph (derived from drug-disease graph links, not product label text):
Upper gastrointestinal: gastritis, duodenitis, achalasia and other oesophageal motility disorders (megaoesophagus, oesophageal dyskinesia)
Mineral metabolism: hypercalcaemia, hyperparathyroidism, osteitis fibrosa, phosphorus metabolism disease
Bone and other: osteonecrosis of the jaw, lytic metastatic bone lesions, sarcoidosis, fibromyalgia, myositis, constipation disorder, pyoureter
Drug Interactions (100 interactions recorded; the 20 listed are all Moderate):
Polyvalent cation products, which reduce absorption: calcium salts (acetate, carbonate, citrate, gluconate, lactate, glubionate, phosphate), magnesium salts and antacids (aluminium hydroxide, magaldrate, magnesium hydroxide/oxide), iron, kaolin and attapulgite
Acetylsalicylic acid
Kanamycin
Dosing separation from these products should be checked against the Product Information. Please also refer to the TGA-approved Product Information (PI) for formal warnings and contraindications.
Disclaimer
This content is for research purposes only and does not constitute medical advice.
Clinical validation is required before any clinical application.